Lincoln Illinois , The Carousel of Progress General Electric , and CircleVision Kodak —already under development, which were used by Disney to sponsor, fund, and test concepts and develop ride systems and innovative entertainment intended to be moved and rebuilt at Disneyland after the World's Fair closed in . The Pepsi Board of Directors took so long to agree on what type of attraction to sponsor that then-board member and widow of past company president Alfred Steele , actress Joan Crawford , prevailed upon her longtime Hollywood friend Walt Disney to design such an attraction as would be suitable for Pepsi. Because of the short lead-time to design, create, and construct such an attraction, she insisted that the board of directors accept his proposal, seeing as he was already designing attractions for the state of Illinois , Ford, General Electric , and Kodak and knew Walt was the only one who could accomplish such a feat in the short time left until the fair was scheduled to open. Like many Disneyland attractions, scenes and characters were designed by Marc Davis , while his wife, Alice Davis , designed the costumes for the dolls.
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Abstract Orexin-A and -B also known as hypocretin-1 and -2 are neuropeptides produced in the lateral hypothalamus that promote many aspects of arousal through the OX1 and OX2 receptors. In fact, they are necessary for normal wakefulness, as loss of the orexin-producing neurons causes narcolepsy in humans and rodents. This has generated considerable interest in developing small-molecule orexin receptor antagonists as a novel therapy for the treatment of insomnia. Orexin antagonists, especially those that block OX2 or both OX1 and OX2 receptors, clearly promote sleep in animals, and clinical results are encouraging: Several compounds are in Phase III trials. As the orexin system mainly promotes arousal, these new compounds will likely improve insomnia without incurring many of the side effects encountered with current medications. Sakurai, Yanagisawa, and colleagues 1 named these peptides orexin-A and -B because they were originally thought to promote feeding the term orexin comes from orexis, the Greek word for appetite.
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